AUTHOR=Wang Keyu , Gong Meiliang , Zhao Sumin , Lai Chengcai , Zhao Lingna , Cheng Sijie , Xia Min , Li Yuru , Wang Kun , Sun Heqiang , Zhu Pingjun , Zhou Yu , Ao Qiangguo , Deng Xinli 

TITLE=A novel lncRNA DFRV plays a dual function in influenza A virus infection

JOURNAL=Frontiers in Microbiology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2023.1171423

DOI=10.3389/fmicb.2023.1171423

ISSN=1664-302X

ABSTRACT=<p>Long noncoding RNAs (lncRNAs) have been associated with a variety of biological activities, including immune responses. However, the function of lncRNAs in antiviral innate immune responses are not fully understood. Here, we identified a novel lncRNA, termed dual function regulating influenza virus (DFRV), elevating in a dose- and time-dependent manner during influenza A virus (IAV) infection, which was dependent on the NFκB signaling pathway. Meanwhile, DFRV was spliced into two transcripts post IAV infection, in which DFRV long suppress the viral replication while DFRV short plays the opposite role. Moreover, DFRV regulates IL-1β and TNF-α via activating several pro-inflammatory signaling cascades, including NFκB, STAT3, PI3K, AKT, ERK1/2 and p38. Besides, DFRV short can inhibit DFRV long expression in a dose-dependent manner. Collectively, our studies reveal that DFRV may act as a potential dual-regulator to preserve innate immune homeostasis in IAV infection.</p>