AUTHOR=Zhang Ling , Zhao Ming , Fu Xiangsheng 

TITLE=Gastric microbiota dysbiosis and Helicobacter pylori infection

JOURNAL=Frontiers in Microbiology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2023.1153269

DOI=10.3389/fmicb.2023.1153269

ISSN=1664-302X

ABSTRACT=<p><italic>Helicobacter pylori</italic> (<italic>H. pylori</italic>) infection is one of the most common causes of gastric disease. The persistent increase in antibiotic resistance worldwide has made <italic>H. pylori</italic> eradication challenging for clinicians. The stomach is unsterile and characterized by a unique niche. Communication among microorganisms in the stomach results in diverse microbial fitness, population dynamics, and functional capacities, which may be positive, negative, or neutral. Here, we review gastric microecology, its imbalance, and gastric diseases. Moreover, we summarize the relationship between <italic>H. pylori</italic> and gastric microecology, including non-<italic>H. pylori</italic> bacteria, fungi, and viruses and the possibility of facilitating <italic>H. pylori</italic> eradication by gastric microecology modulation, including probiotics, prebiotics, postbiotics, synbiotics, and microbiota transplantation.</p>