AUTHOR=Song Ziwei , Sun Yan Jun , Xu Shuangyu , Li Gang , Yuan Chunmao , Zhou Kang 

TITLE=Secondary metabolites from the Endophytic fungi Fusarium decemcellulare F25 and their antifungal activities

JOURNAL=Frontiers in Microbiology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2023.1127971

DOI=10.3389/fmicb.2023.1127971

ISSN=1664-302X

ABSTRACT=<p>Seven new compounds, including three isocoumarins (<bold>1</bold>–<bold>3</bold>), three pyrrolidinone derivatives (<bold>8</bold>–<bold>10</bold>), and one pentaene diacid (<bold>15</bold>), together with 13 known compounds, were isolated from the rice culture of the endophytic fungus <italic>Fusarium decemcellulare</italic> F25. Their structures and stereochemistry were established using HRESIMS, NMR, electronic circular dichroism (ECD) calculations, and single-crystal X-ray diffraction. The possible biosynthetic pathways for compounds <bold>1–3</bold> and <bold>8</bold>–<bold>10</bold> were proposed. The antifungal efficacies of compounds <bold>1 ̶ 20</bold> were evaluated against <italic>Colletotrichum musae</italic>, and compounds <bold>13</bold>, <bold>14</bold>, and <bold>17</bold> exhibited inhibitory activities against <italic>C. musae</italic> with MIC values of 256, 64 and 128 μg/mL, respectively.</p>