AUTHOR=Tu Ye , Kuang Xinyi , Zhang Ling , Xu Xin 

TITLE=The associations of gut microbiota, endocrine system and bone metabolism

JOURNAL=Frontiers in Microbiology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2023.1124945

DOI=10.3389/fmicb.2023.1124945

ISSN=1664-302X

ABSTRACT=<p>Gut microbiota is of great importance in human health, and its roles in the maintenance of skeletal homeostasis have long been recognized as the “gut-bone axis.” Recent evidence has indicated intercorrelations between gut microbiota, endocrine system and bone metabolism. This review article discussed the complex interactions between gut microbiota and bone metabolism-related hormones, including sex steroids, insulin-like growth factors, 5-hydroxytryptamine, parathyroid hormone, glucagon-like peptides, peptide YY, etc. Although the underlying mechanisms still need further investigation, the regulatory effect of gut microbiota on bone health <italic>via</italic> interplaying with endocrine system may provide a new paradigm for the better management of musculoskeletal disorders.</p>