AUTHOR=Fan Yi-Xuan , Andoh Vivian , Chen Liang 

TITLE=Multi-omics study and ncRNA regulation of anti-BmNPV in silkworms, Bombyx mori: an update

JOURNAL=Frontiers in Microbiology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2023.1123448

DOI=10.3389/fmicb.2023.1123448

ISSN=1664-302X

ABSTRACT=<p><italic>Bombyx mori</italic> silkworm is an important economic insect which has a significant contribution to the improvement of the economy. <italic>Bombyx mori</italic> nucleopolyhedrovirus (BmNPV) is a vitally significant purulent virus that impedes the sustainable and stable development of the silkworm industry, resulting in substantial economic losses. In recent years, with the development of biotechnology, transcriptomics, proteomics, metabolomics, and the related techniques have been used to select BmNPV-resistant genes, proteins, and metabolites. The regulatory networks between viruses and hosts have been gradually clarified with the discovery of ncRNAs, such as miRNA, lncRNA, and circRNA in cells. Thus, this paper aims to highlight the results of current multi-omics and ncRNA studies on BmNPV resistance in the silkworm, providing some references for resistant strategies in the silkworm to BmNPV.</p>