AUTHOR=Liu Xijin , Kong Fandong , Xiao Na , Li Xiaoyu , Zhang Mingyu , Lv Fujin , Liu Xiaolin , Kong Xiangchuan , Bi Jing , Lu Xinyi , Kong Daqing , Hao Gangping , Zhou Liman , Pan Guojun 

TITLE=Prenylated indole-terpenoids with antidiabetic activities from Penicillium sp. HFF16 from the rhizosphere soil of Cynanchum bungei Decne

JOURNAL=Frontiers in Microbiology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2023.1099103

DOI=10.3389/fmicb.2023.1099103

ISSN=1664-302X

ABSTRACT=<p>Finding novel and effective suppression of hepatic glucagon response antidiabetic compounds is urgently required for the development of new drugs against diabetes. Fungi are well known for their ability to produce new bioactive secondary metabolites. In this study, four new prenylated indole-terpenoids (<bold>1-4</bold>), named encindolenes I-L, as well as a known analogue (<bold>5</bold>), were isolated from the fungus <italic>Penicillium</italic> sp. HFF16from the rhizosphere soil of <italic>Cynanchum bungei</italic> Decne. The structures of the compounds were elucidated by spectroscopic data and ECD analysis. In the antidiabetic activity assay, compounds <bold>1-5</bold> could inhibit glucagon-induced hepatic glucose output with EC<sub>50</sub> values of 67.23, 102.1, 49.46, 25.20, and 35.96 μM, respectively, and decrease the intracellular cAMP contents in primary hepatocytes.</p>