AUTHOR=Hu Yue , Zhang Xianqin , Deng Shanshan , Yue Changwu , Jia Xu , Lyu Yuhong 

TITLE=Non-antibiotic prevention and treatment against Acinetobacter baumannii infection: Are vaccines and adjuvants effective strategies?

JOURNAL=Frontiers in Microbiology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2023.1049917

DOI=10.3389/fmicb.2023.1049917

ISSN=1664-302X

ABSTRACT=<p><italic>Acinetobacter baumannii</italic> (<italic>A. baumannii</italic>) is a Gram-negative opportunistic pathogen widely attached to the surface of medical instruments, making it one of the most common pathogens of nosocomial infection, and often leading to cross-infection and co-infection. Due to the extensive antibiotic and pan-resistance, <italic>A. baumannii</italic> infection is facing fewer treatment options in the clinic. Therefore, the prevention and treatment of <italic>A. baumannii</italic> infection have become a tricky global problem. The requirement for research and development of the new strategy is urgent. Now, non-antibiotic treatment strategies are urgently needed. This review describes the research on <italic>A. baumannii</italic> vaccines and antibacterial adjuvants, discusses the advantages and disadvantages of different candidate vaccines tested <italic>in vitro</italic> and <italic>in vivo</italic>, especially subunit protein vaccines, and shows the antibacterial efficacy of adjuvant drugs in monotherapy.</p>