AUTHOR=Liu Weidong , Kong Wenjie , Hui Wenjia , Wang Chun , Jiang Qi , Shi Hong , Gao Feng 

TITLE=Characteristics of different types of Helicobacter pylori: New evidence from non-amplified white light endoscopy

JOURNAL=Frontiers in Microbiology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.999564

DOI=10.3389/fmicb.2022.999564

ISSN=1664-302X

ABSTRACT=<sec><title>Background</title><p>Different types of <italic>Helicobacter pylori (H. pylori)</italic> were analyzed to determine their infection characteristics using serology, pathology, and non-magnification white light endoscopy combined with the Kimura–Takemoto classification, and the regular arrangement of collecting venules (RAC) as well.</p></sec><sec><title>Materials and methods</title><p>A retrospective analysis of 685 inpatients who have completed the <sup>14</sup>C-urea breath test, the <italic>H. pylori</italic> antibody typing classification, the serum gastric function tests (PGI/PGII/G-17), the endoscope detection, and the pathological examinations.</p></sec><sec><title>Results</title><p>The levels of PGI, PGII, and G-17 were in descending order from the type I <italic>H. pylori</italic> infection group to the type II <italic>H. pylori</italic> infection group than the control group (<italic>F</italic> = 14.31; 26.23; 9.12, <italic>P</italic> &lt; 0.01). Using the Kimura–Takemoto classification, there were significant differences among the three groups of different degrees of atrophy (<inline-formula><mml:math id="M1" xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msup><mml:mi>χ</mml:mi><mml:mn>2</mml:mn></mml:msup></mml:mrow></mml:math></inline-formula>=29.81; 482.78; 292.5, <italic>P&lt;</italic> 0.01). Based on the characteristics of RAC, the <italic>H. pylori</italic> infection rates were in descending order from the type I <italic>H. pylori</italic> infection group to the type II <italic>H. pylori</italic> infection group than the control group (<inline-formula><mml:math id="M2" xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msup><mml:mi>χ</mml:mi><mml:mn>2</mml:mn></mml:msup><mml:mspace width="thickmathspace" /></mml:mrow></mml:math></inline-formula>= 200.39; 174.72; 143.51, <italic>P</italic> &lt; 0.01). The type I <italic>H. pylori</italic> infection group had higher grades than those of the type II <italic>H. pylori</italic> infection group in the OLGA and OLGIM staging systems, while the differences are statistically significant only in the OLGA staging system (<inline-formula><mml:math id="M3" xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msup><mml:mi>χ</mml:mi><mml:mn>2</mml:mn></mml:msup></mml:mrow></mml:math></inline-formula>=10.63, <italic>P</italic> &lt; 0.05).</p></sec><sec><title>Conclusion</title><p>With the aid of non-amplified white light endoscopy, we found new evidence of type I <italic>H. pylori</italic> infection accelerating the progression of gastric mucosal atrophy through the degree of atrophy and the range of infection, whereas type II <italic>H. pylori</italic> infection has a low ability of migration and atrophy progression. Individual virulence factor-based eradication therapy may be a better choice in future.</p></sec>