AUTHOR=Liu Weidong , Kong Wenjie , Hui Wenjia , Wang Chun , Jiang Qi , Shi Hong , Gao Feng 

TITLE=Characteristics of different types of Helicobacter pylori: New evidence from non-amplified white light endoscopy

JOURNAL=Frontiers in Microbiology

VOLUME=Volume 13 - 2022

YEAR=2023

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.999564

DOI=10.3389/fmicb.2022.999564

ISSN=1664-302X

ABSTRACT=Background: Different types of H. pylori were analyzed to determine their infection characteristics by means of serology, pathology, non-magnification white light endoscopy combined with Kimura-Takemoto classification and the regular arrangement of collecting venules (RAC) as well. 
Materials and Methods: Retrospective analysis of 685 inpatients who have completed the 14C-urea breath test, the H. pylori antibody typing classifcation, the serum gastric function tests (PGI/PGII/G-17), the endoscope detection and the pathological examinations. 
Results: The levels of PGI, PGII and G-17 were in descending order from the type I H. pylori infection group to the type II H. pylori infection group than the control group (F= 14.31; 26.23; 9.12, P< 0.01). Using Kimura-Takemoto classification, there were significant differences among the three groups of different degrees of atrophy (= 143.91; 359.54; 200.01; 174.46; 143.3, P all < 0.01). Based on the characteristics of RAC, the H. pylori infection rates were in descending order from the type I H. pylori infection group to the type II H. pylori infection group than the control group (= 200.39; 174.72; 143.51, P < 0.01). Type I H. pylori infection group had higher grades than those of the type II H. pylori infection group in the OLGA and OLGIM staging system, while only in the OLGA stage system had statistically significant (Z =-2.96, P < 0.01). 
Conclusion: With the aid of non-amplified white light endoscopy, we found new evidence of type I H. pylori infection accelerating the progression of gastric mucosal atrophy through the degree of atrophy and the range of infection, whereas type II H. pylori infection has a low ability of migration and atrophy progression. Individual eradication therapy based on virulence factors may be a better choice.