AUTHOR=Li Zhuang , Meng Lu , Ma Qingyun , Wang Zhen , Zhao Youxing , Luo Duqiang 

TITLE=Polyketides with IDH1 R132h and PTP1B inhibitory activities from the desert-plant-derived fungus Alternaria sp. HM 134

JOURNAL=Frontiers in Microbiology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.975579

DOI=10.3389/fmicb.2022.975579

ISSN=1664-302X

ABSTRACT=<p>Five new polyketides named alternafurones A (<bold>1</bold>) and B (<bold>2</bold>), alternapyrones M-O (<bold>3</bold>–<bold>5</bold>), together with fourteen known ones (<bold>6</bold>–<bold>19</bold>), were isolated from the desert-plant-derived fungus <italic>Alternaria</italic> sp. HM 134. The structures of the new compounds were elucidated from spectroscopic data and ECD spectroscopic analyses. Alternafurones A and B represent polyketides with an unprecedented 6/5/6 skeleton core. Compounds <bold>1</bold>, <bold>2</bold> and <bold>4</bold> showed definite inhibitory activities against isocitrate dehydrogenase 1 gene (IDH1 R132h) with IC<sub>50</sub> values of 29.38, 19.41 and 14.14 μg/ml, respectively. Seven compounds (<bold>6</bold>, <bold>7</bold>, <bold>9</bold>–<bold>12</bold>, <bold>14</bold>) showed potent protein tyrosine phosphatase 1B (PTP1B) inhibitory activity with IC<sub>50</sub> values ranging from 0.97 μg/ml to 89.80 μg/ml.</p>