AUTHOR=Ning Yaru , Huang Yalin , Wang Mingshu , Cheng Anchun , Yang Qiao , Wu Ying , Tian Bin , Ou Xumin , Huang Juan , Mao Sai , Sun Di , Zhao Xinxin , Zhang Shaqiu , Gao Qun , Chen Shun , Liu Mafeng , Zhu Dekang , Jia Renyong TITLE=Alphaherpesvirus glycoprotein E: A review of its interactions with other proteins of the virus and its application in vaccinology JOURNAL=Frontiers in Microbiology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.970545 DOI=10.3389/fmicb.2022.970545 ISSN=1664-302X ABSTRACT=

The viral envelope glycoprotein E (gE) is required for cell-to-cell transmission, anterograde and retrograde neurotransmission, and immune evasion of alphaherpesviruses. gE can also interact with other proteins of the virus and perform various functions in the virus life cycle. In addition, the gE gene is often the target gene for the construction of gene-deleted attenuated marker vaccines. In recent years, new progress has been made in the research and vaccine application of gE with other proteins of the virus. This article reviews the structure of gE, the relationship between gE and other proteins of the virus, and the application of gE in vaccinology, which provides useful information for further research on gE.