AUTHOR=Alam Khorshed , Mazumder Arpita , Sikdar Suranjana , Zhao Yi-Ming , Hao Jinfang , Song Chaoyi , Wang Yanyan , Sarkar Rajib , Islam Saiful , Zhang Youming , Li Aiying 

TITLE=Streptomyces: The biofactory of secondary metabolites

JOURNAL=Frontiers in Microbiology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.968053

DOI=10.3389/fmicb.2022.968053

ISSN=1664-302X

ABSTRACT=<p>Natural products derived from microorganisms serve as a vital resource of valuable pharmaceuticals and therapeutic agents. <italic>Streptomyces</italic> is the most ubiquitous bacterial genus in the environments with prolific capability to produce diverse and valuable natural products with significant biological activities in medicine, environments, food industries, and agronomy sectors. However, many natural products remain unexplored among <italic>Streptomyces</italic>. It is exigent to develop novel antibiotics, agrochemicals, anticancer medicines, etc., due to the fast growth in resistance to antibiotics, cancer chemotherapeutics, and pesticides. This review article focused the natural products secreted by <italic>Streptomyces</italic> and their function and importance in curing diseases and agriculture. Moreover, it discussed genomic-driven drug discovery strategies and also gave a future perspective for drug development from the <italic>Streptomyces</italic>.</p>