AUTHOR=Cui Tongxu , Lin Simin , Wang Zizhen , Fu Peng , Wang Cong , Zhu Weiming 

TITLE=Cytotoxic Indolocarbazoles From a Marine-Derived Streptomyces Sp. OUCMDZ-5380

JOURNAL=Frontiers in Microbiology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.957473

DOI=10.3389/fmicb.2022.957473

ISSN=1664-302X

ABSTRACT=<p>Under the guidance of global natural product social molecular networking, three new indolocarbazoles named streptocarbazoles F–H (<bold>1</bold>-<bold>3</bold>), along with staurosporine (<bold>4</bold>) were isolated from the marine-derived <italic>Streptomyces</italic> sp. OUCMDZ-5380. Structures of streptocarbazoles F–H were, respectively, determined as <italic>N</italic>-demethyl-<italic>N</italic>-hexanoylstaurosporine (<bold>1</bold>), <italic>N</italic>-demethyl-<italic>N</italic>-(2-methyl-3-methoxypyridin-4-yl) staurosporine staurosporine (<bold>2</bold>), and 4-(<italic>N</italic>-demethylstaurosporine-<italic>N</italic>-yl)-1,2-dimethyl-3-methoxypyridinium (<bold>3</bold>) by spectroscopic analysis and electronic circular dichroism comparison with staurosporine. Compared with staurosporine (<bold>4</bold>), streptocarbazoles F–H (<bold>1</bold>-<bold>3</bold>) showed a selective antiproliferation of the acute myeloid leukemia cell line MV4-11 with the IC<sub>50</sub> values of 0.81, 0.55, and 1.88 μM, respectively.</p>