AUTHOR=Lv Dongli , Xia Jinmei , Guan Xiaoqing , Lai Qiliang , Zhang Beibei , Lin Jianhui , Shao Zongze , Luo Sulan , Zhangsun Dongting , Qin Jiang-Jiang , Wang Weiyi 

TITLE=Indole Diketopiperazine Alkaloids Isolated From the Marine-Derived Fungus Aspergillus chevalieri MCCC M23426

JOURNAL=Frontiers in Microbiology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.950857

DOI=10.3389/fmicb.2022.950857

ISSN=1664-302X

ABSTRACT=<p>Two new indole diketopiperazines (<bold>1–2</bold>) obtained from the fermentation culture of a deep-sea-derived fungus <italic>Aspergillus chevalieri</italic> MCCC M23426, were characterized, together with nine biogenetic related compounds (<bold>3–11</bold>). The structures of <bold>1–2</bold> were assigned based on NMR, MS, NMR calculation, DP4+ analysis, and ECD calculation. The bioactive assay showed that compounds <bold>1</bold>, <bold>5</bold>–<bold>7</bold> significantly inhibited the growth of <italic>Staphylococcus aureus</italic>. Meanwhile, compound <bold>8</bold> potently reduced the cell viability of gastric cancer cell MKN1 with an IC<sub>50</sub> value of 4.6 μM.</p>