AUTHOR=Wong Kuan Yee , Megat Mazhar Khair Megat Hamzah , Song Adelene Ai-Lian , Masarudin Mas Jaffri , Chong Chou Min , In Lionel Lian Aun , Teo Michelle Yee Mun TITLE=Endolysins against Streptococci as an antibiotic alternative JOURNAL=Frontiers in Microbiology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.935145 DOI=10.3389/fmicb.2022.935145 ISSN=1664-302X ABSTRACT=
Multi-drug resistance has called for a race to uncover alternatives to existing antibiotics. Phage therapy is one of the explored alternatives, including the use of endolysins, which are phage-encoded peptidoglycan hydrolases responsible for bacterial lysis. Endolysins have been extensively researched in different fields, including medicine, food, and agricultural applications. While the target specificity of various endolysins varies greatly between species, this current review focuses specifically on streptococcal endolysins.