AUTHOR=Li Hao , Miao Ming-xing , Jia Cheng-lin , Cao Yong-bing , Yan Tian-hua , Jiang Yuan-ying , Yang Feng 

TITLE=Interactions between Candida albicans and the resident microbiota

JOURNAL=Frontiers in Microbiology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.930495

DOI=10.3389/fmicb.2022.930495

ISSN=1664-302X

ABSTRACT=<p><italic>Candida albicans</italic> is a prevalent, opportunistic human fungal pathogen. It usually dwells in the human body as a commensal, however, once in its pathogenic state, it causes diseases ranging from debilitating superficial to life-threatening systemic infections. The switch from harmless colonizer to virulent pathogen is, in most cases, due to perturbation of the fungus-host-microbiota interplay. In this review, we focused on the interactions between <italic>C. albicans</italic> and the host microbiota in the mouth, gut, blood, and vagina. We also highlighted important future research directions. We expect that the evaluation of these interplays will help better our understanding of the etiology of fungal infections and shed new light on the therapeutic approaches.</p>