AUTHOR=Dussert Elodie , Tourret Mélissa , Dupuis Chloé , Noblecourt Alexandre , Behra-Miellet Josette , Flahaut Christophe , Ravallec Rozenn , Coutte François 

TITLE=Evaluation of Antiradical and Antioxidant Activities of Lipopeptides Produced by Bacillus subtilis Strains

JOURNAL=Frontiers in Microbiology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.914713

DOI=10.3389/fmicb.2022.914713

ISSN=1664-302X

ABSTRACT=This study investigated the antiradical and antioxidant potential of the three families of lipopeptides (surfactin, mycosubtilin and plipastatin) produced by Bacillus subtilis strains. The antiradical/antioxidant activities of the lipopeptides were studied in acellular models using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical, superoxide anion (O2.-), hydrogen peroxide (H2O2) and hydroxyl radical (HO.). At a lipopeptide concentration of 500 mg.L-1, the maximum inhibition of DPPH reached 22.88% (obtained for plipastatin). Moreover, the scavenging effect of O2.-, H2O2 and HO. at the highest concentration tested (250 mg.L-1) were found to be 6%, 21% and 3% for surfactin; 19%, 9% and 15% for mycosubtilin; 21%, 18% and 59% for plipastatin; 21%, 31% and 61% for the mix surfactin/plipastatin and 13%, 16% and 15% for the mixture surfactin/mycosubtilin, respectively. These results showed that plipastatin was the best candidate regarding its antioxidant activities.