AUTHOR=Aravindhan Vivekanandhan , Bobhate Anup , Sathishkumar Kuppan , Patil Aruna , Kumpatla Satyavani , Viswanathan Vijay 

TITLE=Unique Reciprocal Association Seen Between Latent Tuberculosis Infection and Diabetes Is Due to Immunoendocrine Modulation (DM-LTB-1)

JOURNAL=Frontiers in Microbiology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.884374

DOI=10.3389/fmicb.2022.884374

ISSN=1664-302X

ABSTRACT=<sec><title>Aim</title><p>The prevalence of latent tuberculosis infection (LTBI) among diabetes patients is poorly studied. In the present study, the prevalence of LTBI among pre-diabetes and diabetes patients was studied, along with immunoendocrine biomarkers (<italic>n</italic> = 804).</p></sec><sec><title>Methods</title><p>LTBI was screened by Quantiferon TB gold in Normal glucose tolerance [(NGT); <italic>n</italic> = 170, [Pre-diabetes (PDM; <italic>n</italic> = 209), Newly diagnosed diabetes (NDM; <italic>n</italic> = 165) and Known diabetes (KDM; <italic>n</italic> = 260) subjects. CRP, TNF-α, IL-6, IL-1β, IFN-β, IL-12, IFN-γ, IL-2, insulin, leptin, and adiponectin levels in serum and IFN-γ levels in quantiferon supernatants were quantified by ELISA. The expression of T-bet was quantified using qRT-PCR. Serum TBARS and nitrite levels were quantified by colorimetry.</p></sec><sec><title>Results</title><p>The LTBI prevalence was 32% in NGT, 23% in PDM, 24% in NDM, and 32% in KDM groups, with an adjusted OR of 0.61 (<italic>p</italic> &lt; 0.05). Downregulation of CRP, TNF-α, and nitrites and upregulation of adiponectin could be responsible for LTBI mediated protection against insulin resistance (IR), while the high levels of IL-1β, IL-12, and leptin could be responsible for IR mediated anti-TB immunity. The defective antigen-specific IFN-γ response, as seen in the KDM group, could be responsible for the low detection rate of LTBI and high probability of endogenous reactivation.</p></sec><sec><title>Conclusion</title><p>There appears to be a biphasic relationship between diabetes-latent tuberculosis: At the early stages of diabetes it is reciprocal, while at a late stage it is synergistic, this important phenomenon obviously needs further research.</p></sec>