AUTHOR=Janda Ales , Engel Corinna , Remppis Jonathan , Enkel Sigrid , Peter Andreas , Hörber Sebastian , Ganzenmueller Tina , Schober Sarah , Weinstock Christof , Jacobsen Eva-Maria , Fabricius Dorit , Zernickel Maria , Stamminger Thomas , Dietz Andrea , Groß Hans-Jürgen , Bode Sebastian F. N. , Haddad Anneke D. M. , Elling Roland , Stich Maximilian , Tönshoff Burkhard , Henneke Philipp , Debatin Klaus-Michael , Franz Axel R. , Renk Hanna TITLE=Role of ABO Blood Group in SARS-CoV-2 Infection in Households JOURNAL=Frontiers in Microbiology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.857965 DOI=10.3389/fmicb.2022.857965 ISSN=1664-302X ABSTRACT=

An association between certain ABO/Rh blood groups and susceptibility to SARS-CoV-2 infection has been proposed for adults, although this remains controversial. In children and adolescents, the relationship is unclear due to a lack of robust data. Here, we investigated the association of ABO/Rh blood groups and SARS-CoV-2 in a multi-center study comprising 163 households with 281 children and 355 adults and at least one SARS-CoV-2 seropositive individual as determined by three independent assays as a proxy for previous infection. In line with previous findings, we found a higher frequency of blood group A (+ 6%) and a lower frequency of blood group O (−6%) among the SARS-CoV-2 seropositive adults compared to the seronegative ones. This trend was not seen in children. In contrast, SARS-CoV-2 seropositive children had a significantly lower frequency of Rh-positive blood groups. ABO compatibility did not seem to play a role in SARS-CoV-2 transmission within the families. A correction for family clusters was performed and estimated fixed effects of the blood group on the risk of SARS-CoV-2 seropositivity and symptomatic infection were determined. Although we found a different distribution of blood groups in seropositive individuals compared to the reference population, the risk of SARS-CoV-2 seropositivity or symptomatic infection was not increased in children or in adults with blood group A or AB versus O or B. Increasing age was the only parameter positively correlating with the risk of SARS-CoV-2 infection. In conclusion, specific ABO/Rh blood groups and ABO compatibility appear not to predispose for SARS-CoV-2 susceptibility in children.