AUTHOR=Wendisch Volker F. , Nampoothiri K. Madhavan , Lee Jin-Ho 

TITLE=Metabolic Engineering for Valorization of Agri- and Aqua-Culture Sidestreams for Production of Nitrogenous Compounds by Corynebacterium glutamicum

JOURNAL=Frontiers in Microbiology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.835131

DOI=10.3389/fmicb.2022.835131

ISSN=1664-302X

ABSTRACT=<p><italic>Corynebacterium glutamicum</italic> is used for the million-ton-scale production of amino acids. Valorization of sidestreams from agri- and aqua-culture has focused on the production of biofuels and carboxylic acids. Nitrogen present in various amounts in sidestreams may be valuable for the production of amines, amino acids and other nitrogenous compounds. Metabolic engineering of <italic>C. glutamicum</italic> for valorization of agri- and aqua-culture sidestreams addresses to bridge this gap. The product portfolio accessible <italic>via C. glutamicum</italic> fermentation primarily features amino acids and diamines for large-volume markets in addition to various specialty amines. On the one hand, this review covers metabolic engineering of <italic>C. glutamicum</italic> to efficiently utilize components of various sidestreams. On the other hand, examples of the design and implementation of synthetic pathways not present in native metabolism to produce sought after nitrogenous compounds will be provided. Perspectives and challenges of this concept will be discussed.</p>