AUTHOR=Li Pinglu , Chen Shuyue , Li Ping , Xu Dan , Tang Xueyuan , Liao Junlin , Xie Hongju , Li Gaofeng , Kuang Yehong , Su Juan , Tang Shijie , Zhou Jianda 

TITLE=Treatment of Axillary Osmidrosis by Rebalancing Skin Microecology With Lactobacillus bulgaricus

JOURNAL=Frontiers in Microbiology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.821696

DOI=10.3389/fmicb.2022.821696

ISSN=1664-302X

ABSTRACT=<p><italic>Corynebacterium</italic> accounts for around 20% of the armpit microbiome and plays an essential role in axillary osmidrosis (AO). In this study, the effects of <italic>Lactobacillus bulgaricus</italic> treatment on the microecological environment of armpits and its efficacy in the treatment of AO were investigated. A total of 10 AO patients were enrolled in this study. The patients were treated with <italic>L. bulgaricus</italic> mixed with saline on the left armpit (experimental group) and pure saline on the right armpit (control group) for 28 days. After treatment, AO severity showed a significant decrease (<italic>p</italic> = 0.013) in the experimental group compared with the control group, and the <italic>Corynebacterium</italic> abundance also showed a corresponding significant decrease (<italic>p</italic> &lt; 0.01). Moreover, no significant variation in <italic>Staphylococcus</italic> abundance was found between these two groups. The microbe diversity is not disturbed in the treatment. Accordingly, our study demonstrates that <italic>L. bulgaricus</italic> can serve as an effective probiotic microbe for AO treatment by reducing the abundance of <italic>Corynebacterium</italic> and rebalancing the microecological environment.</p>