AUTHOR=Peng Xiao-Ping , Li Gang , Wang Li-Mei , Wang Qi , Wang Cong , Ji Li-Xia , Cao Chen-Xi , Lin Guo-Feng , Jiang Zu-Yang , He Zhuo-qian , Wang Pei , Lou Hong-Xiang 

TITLE=Structurally Various Sorbicillinoids From an Endophytic Fungus Acremonium citrinum SS-g13

JOURNAL=Frontiers in Microbiology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.800626

DOI=10.3389/fmicb.2022.800626

ISSN=1664-302X

ABSTRACT=<p>Three new sorbicillinoids, including trimer trisorbicillinone E (<bold>1</bold>), acremosorbicillinoids A and B (<bold>2</bold> and <bold>3</bold>), and a new alkaloid acremokaloid A (<bold>4</bold>), and a new natural product 2<italic>S</italic>,3<italic>S</italic>-acetyl-β-methyltryptophan (<bold>5</bold>), were isolated from an endophytic fungus <italic>Acremonium citrinum</italic> SS-g13, which is found in <italic>Fructus mori</italic> plant root. In addition, eight known sorbicillinoids (<bold>6–13</bold>) were also obtained. The new compound structures were established using NMR, HRESIMS spectra, and reported spectroscopic data. The absolute configurations of compounds <bold>1–5</bold>, were determined by spectroscopic analysis, Snatzke’s method, and time-dependent density functional theory-electronic circular dichroism (TDDFT-ECD) calculations. Compound <bold>11</bold> exhibited significant cholesterol efflux enhancing activity. A plausible biosynthesis pathway for the sorbicillinoids is discussed.</p>