AUTHOR=da Silva Torres Maria Karoliny , Bichara Carlos David Araújo , de Almeida Maria de Nazaré do Socorro , Vallinoto Mariana Cayres , Queiroz Maria Alice Freitas , Vallinoto Izaura Maria Vieira Cayres , dos Santos Eduardo José Melo , de Carvalho Carlos Alberto Marques , Vallinoto Antonio Carlos R. TITLE=The Complexity of SARS-CoV-2 Infection and the COVID-19 Pandemic JOURNAL=Frontiers in Microbiology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.789882 DOI=10.3389/fmicb.2022.789882 ISSN=1664-302X ABSTRACT=

The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to the death of millions of people worldwide and thousands more infected individuals developed sequelae due to the disease of the new coronavirus of 2019 (COVID-19). The development of several studies has contributed to the knowledge about the evolution of SARS-CoV2 infection and the disease to more severe forms. Despite this information being debated in the scientific literature, many mechanisms still need to be better understood in order to control the spread of the virus and treat clinical cases of COVID-19. In this article, we carried out an extensive literature review in order to bring together, in a single article, the biological, social, genetic, diagnostic, therapeutic, immunization, and even socioeconomic aspects that impact the SAR-CoV-2 pandemic. This information gathered in this article will enable a broad and consistent reading of the main aspects related to the current pandemic.