Qiaocheng Chang
Ze Chen
Michael E. von Fricken
Quan Liu- 1School of Public Health, Shantou University, Shantou, China
- 2Hebei Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology, College of Life Sciences, Hebei Normal University, Shijiazhuang, China
- 3Department of Global and Community Health, George Mason University, Fairfax, VA, United States
- 4Department of Infectious Diseases, Center of Infectious Diseases and Pathogen Biology, The First Hospital, Jilin University, Changchun, China
- 5School of Life Science and Engineering, Foshan University, Foshan, China
Editorial on the Research Topic
New infectious agents in arthropod vectors
Vector-borne infectious diseases are an important global public health concern, with new pathogens emerging over the past few decades due to the socioeconomic, environmental, and climate change factors (Chala and Hamde, 2021). New detection methods, including virome, meta-transcriptome, metagenome, as well as other specific sequencing and molecular technologies, are widely being deployed for detecting emerging and re-emerging vector-borne pathogens (Angelakis and Raoult, 2014; Epstein and Anthony, 2017). Using these techniques, a large number of new pathogens, including viruses, bacteria, fungi, protozoan and helminth parasites, from both animal hosts and medically relevant vectors, have been discovered (Ma et al., 2021; Zhang et al., 2022). High resolution sequence data generated from these efforts are important for both clinical and public health countermeasures, including prevention, treatment, surveillance, and control. This information combined with biological evidence of transmission can aid in the determination and classification of new infectious agents.
Colpodella species are a group of free-living small predatory flagellates related to apicomplexans (Yuan et al., 2012). Under this special topic, Xu et al. reported Colpodella spp. infection in horses using PCR assay. Ixodes persulcatus may serve as the possible vector for Colpodella spp., which is associated with neurological disease in immunocompromised individuals (Jiang et al., 2018). Further investigation should be conducted to determine the roles of horses in the transmission of this new discovered pathogen and to identify the clinical symptoms of horses infected with Colpodella spp.. He et al. conducted a thorough and broad-range investigation of Borrelia burgdorferi sensu lato in domestic mammals, small wild mammals and ticks collected from Yunnan Province, China. Six genospecies, including B. burgdorferi sensu stricto, B. afzelii, B. garinii, B. japonica, B. sinica, and B. valaisiana were detected positive, indicating a wide distribution of multiple Borrelia genospecies in Yunnan, China. Guo et al. investigated the virome of Rhipicephalus ticks in Guangdong Province, southern China, and a total of ten viruses, including three phenuivruses, two chuviruses, one each rhabdovirus, flavivirus, orthomyxovirus, and reovirus, and an unclassified virus (Guangdong tick Manly virus), were identified using meta-transcriptome analysis. Importantly, most of these viruses were genetically associated with the viruses reported in Turkey, Trinidad and Tobago, Australia, Thailand, northern Europe, and Brazil, suggesting that it is necessary to continuously survey tick-borne viruses in southern China.
Lin et al. reported high prevalence of Rickettsia spp. in Dermacentor everestianus and Haemaphysalis qinghaiensis ticks collected from yaks in Shiqu county, eastern Tibetan Plateau, China. In this region, the primary mammalian hosts of ticks included domesticated yaks and wild mammals, such as rodents and plateau pika. Lu et al. revealed a high diversity of Anaplasma, Ehrlichia, and Rickettsia in ticks collected from Yunnan Province, and a novel species of Rickettsia was identified. Moreover, most of these bacteria can cause diseases in humans, such as E. canis, E. chaffeensis, and A. ovis, with high infection rates in these detected ticks. Therefore, there is potential risk of zoonoses transmitted from ticks to humans, resulting from the frequent contact between humans and domestic animals (goats and cattle) that act as tick hosts in these regions. Zawada et al. described high levels of B. burgdorferi genetic diversity in white-footed mice, with tongue and ear samples containing 90% of detected subtypes. The work emphasized the need to incorporate metagenomic sequencing into ongoing Lyme disease surveillance efforts.
Alongshan virus (ALSV) is a newly discovered segmented tick-borne flavivirus that can cause human febrile illness (Wang et al., 2019). The viral genome contains four segments and encodes the structural proteins of VP1-VP4 and non-structural proteins of NSP1 and NSP2. Zhao et al. investigated the subcellular distribution and possible functions of viral proteins in host cells, and found that the ALSV proteins had distinct subcellular distribution in different tissue-deriving cells, and caused endoplasmic reticulum morphological changes, and NSP1 could induce mitophagy to reduce mitochondria quantity. These findings help to understand the pathogenic mechanisms of emerging segmented flaviviruses. Babesia microti, a tick-transmitted hematoprotozoan, can infect small rodents and humans (Gray and Ogden, 2021). Shu et al. found that B. microti can effectively suppress melanoma cell growth and extend the survival time of tumor-bearing mice through increasing the number of CD4+ T cells and macrophages and inducing the conversion of macrophages from type M2 to M1. However, the macrophage activation mechanisms by B. microti remains to be explained.
The Topic was intended to focus on new infectious agents in mosquitoes, ticks, fleas, flies, midges, and other blood-sucking arthropods. However, a majority of submitted and all accepted manuscripts focused on tick-borne pathogens in China. These results suggest a high diversity of tick-borne pathogens in China, especially viruses and bacteria, whose epidemiology, biology and public health significance should be further investigated. Moreover, further Research Topics specific to other medically relevant arthropods vectors is recommended.
Author contributions
QL and QC drafted the manuscript. All authors corrected, edited, and approved the manuscript. All authors listed have made a substantial, direct, and intellectual contribution to the work and approved it for publication.
Funding
This work was supported by the Science and Technology Plan Medical and Health Category Project of Shantou (Grant No. 220511176491121), the National Natural Science Foundation of China (32072885), the STU Scientific Research Foundation for Talents (NTF21043), the Pearl River Talent Plan in Guangdong Province of China (2019CX01N111), and the Medical Innovation Team Project of Jilin University (2022JBGS02).
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher's note
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References
Angelakis, E., and Raoult, D. (2014). Methods for the discovery of emerging pathogens. Microb. Pathog. 77, 114–118. doi: 10.1016/j.micpath.2014.06.007
Chala, B., and Hamde, F. (2021). Emerging and re-emerging vector-borne infectious diseases and the challenges for control: a review. Front. Public Health. 9, 715759. doi: 10.3389/fpubh.2021.715759
Epstein, J. H., and Anthony, S. J. (2017). Viral discovery as a tool for pandemic preparedness. Rev. Sci. Tech. 36, 499–512. doi: 10.20506/rst.36.2.2669
Gray, J. S., and Ogden, N. H. (2021). Ticks, human babesiosis and climate change. Pathogens. 10, 1430. doi: 10.3390/pathogens10111430
Jiang, J. F., Jiang, R. R., Chang, Q. C., Zheng, Y. C., Jiang, B. G., Sun, Y., et al. (2018). Potential novel tick-borne Colpodella species parasite infection in patient with neurological symptoms. PLoS Negl. Trop. Dis. 12, e0006546. doi: 10.1371/journal.pntd.0006546
Ma, J., Lv, X. L., Zhang, X., Han, S. Z., Wang, Z. D., Li, L., et al. (2021). Identification of a new orthonairovirus associated with human febrile illness in China. Nat. Med. 27, 434–439. doi: 10.1038/s41591-020-01228-y
Wang, Z. D., Wang, B., Wei, F., Han, S. Z., Zhang, L., Yang, Z. T., et al. (2019). A new segmented virus associated with human febrile illness in China. N. Engl. J. Med. 380, 2116–2125. doi: 10.1056/NEJMoa1805068
Yuan, C. L., Keeling, P. J., Krause, P. J., Horak, A., Bent, S., Rollend, L., et al. (2012). Colpodella spp.-like parasite infection in woman, China. Emerg. Infect. Dis. 18, 125–127. doi: 10.3201/eid1801.110716
Keywords: new infectious agents, virome, metagenome, vertebrate hosts, arthropod vectors
Citation: Chang Q, Chen Z, von Fricken ME and Liu Q (2022) Editorial: New infectious agents in arthropod vectors. Front. Microbiol. 13:1105082. doi: 10.3389/fmicb.2022.1105082
Received: 22 November 2022; Accepted: 30 November 2022;
Published: 09 December 2022.
Edited and reviewed by: Axel Cloeckaert, Institut National de recherche pour l'agriculture, l'alimentation et l'environnement (INRAE), France
Copyright © 2022 Chang, Chen, von Fricken and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Quan Liu, bGl1cXVhbjE5NzMmI3gwMDA0MDtob3RtYWlsLmNvbQ==