AUTHOR=Flórez-Álvarez Lizdany , de Souza Edmarcia Elisa , Botosso Viviane Fongaro , de Oliveira Danielle Bruna Leal , Ho Paulo Lee , Taborda Carlos Pelleschi , Palmisano Giuseppe , Capurro Margareth Lara , Pinho João Renato Rebello , Ferreira Helena Lage , Minoprio Paola , Arruda Eurico , de Souza Ferreira Luís Carlos , Wrenger Carsten , Durigon Edison Luiz TITLE=Hemorrhagic fever viruses: Pathogenesis, therapeutics, and emerging and re-emerging potential JOURNAL=Frontiers in Microbiology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.1040093 DOI=10.3389/fmicb.2022.1040093 ISSN=1664-302X ABSTRACT=

Hemorrhagic fever viruses (HFVs) pose a threat to global public health owing to the emergence and re-emergence of highly fatal diseases. Viral hemorrhagic fevers (VHFs) caused by these viruses are mostly characterized by an acute febrile syndrome with coagulation abnormalities and generalized hemorrhage that may lead to life-threatening organ dysfunction. Currently, the events underlying the viral pathogenicity associated with multiple organ dysfunction syndrome still underexplored. In this minireview, we address the current knowledge of the mechanisms underlying VHFs pathogenesis and discuss the available development of preventive and therapeutic options to treat these infections. Furthermore, we discuss the potential of HFVs to cause worldwide emergencies along with factors that favor their spread beyond their original niches.