AUTHOR=Li Zitong , Ke Haoran , Wang Ying , Chen Shuze , Liu Xiuying , Lin Qianyun , Wang Pu , Chen Ye 

TITLE=Global trends in Akkermansia muciniphila research: A bibliometric visualization

JOURNAL=Frontiers in Microbiology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.1037708

DOI=10.3389/fmicb.2022.1037708

ISSN=1664-302X

ABSTRACT=<sec><title>Background</title><p><italic>Akkermansia muciniphila</italic> is a member of the gut microbiome, using mucin as sources of carbon, nitrogen, and energy. Since the first discovery of this unique bacterium in 2004, <italic>A. muciniphila</italic> has been extensively studied. It is considered a promising “next-generation beneficial microbe.” The purpose of this paper is to sort out the research status and summarize the hotspots through bibliometric analysis of the publications of <italic>A. muciniphila.</italic></p></sec><sec><title>Methods</title><p>The publications about <italic>A. muciniphila</italic> from January 2004 to February 2022 were obtained from the Web of Science Core Collection. Visualization analyses were performed using three bibliometric tools and GraphPad Prism.</p></sec><sec><title>Results</title><p>A total of 1,478 published documents were analyzed. Annual publication number grew from 1 in 2004 to 336 in 2021, with China being the leading producer (33.36%). De Vos, Willem M was the most productive author with the highest H-index (documents = 56, H-index = 37), followed by Cani, Patrice D (documents = 35, H-index = 25). And Scientific Reports published the most papers. <italic>PNAS</italic> was the keystone taxa in this field, with high betweenness centrality (0.11) and high frequency. The keywords with high frequency in recent years include: oxidative stress, diet, metformin, fecal microbiota transplantation, short-chain fatty acids, polyphenols, microbiota metabolites and so on. The keyword “oxidative stress” was observed to be increasing in frequency recently.</p></sec><sec><title>Conclusion</title><p>Over time, the scope of the research on the clinical uses of <italic>A. muciniphila</italic> has gradually increased, and was gradually deepened and developed toward a more precise level. <italic>A. muciniphila</italic> is likely to remain a research hotspot in the foreseeable future and may contribute to human health.</p></sec>