AUTHOR=Kar Joyeeta , Ramrao Devde Pandurang , Zomuansangi Ruth , Lalbiaktluangi C. , Singh Shiv Mohan , Joshi Naveen Chandra , Kumar Ajay , Kaushalendra , Mehta Suryakant , Yadav Mukesh Kumar , Singh Prashant Kumar TITLE=Revisiting the role of cyanobacteria-derived metabolites as antimicrobial agent: A 21st century perspective JOURNAL=Frontiers in Microbiology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.1034471 DOI=10.3389/fmicb.2022.1034471 ISSN=1664-302X ABSTRACT=

Cyanobacterial species are ancient photodiazotrophs prevalent in freshwater bodies and a natural reservoir of many metabolites (low to high molecular weight) such as non-ribosomal peptides, polyketides, ribosomal peptides, alkaloids, cyanotoxins, and isoprenoids with a well-established bioactivity potential. These metabolites enable cyanobacterial survival in extreme environments such as high salinity, heavy metals, cold, UV-B, etc. Recently, these metabolites are gaining the attention of researchers across the globe because of their tremendous applications as antimicrobial agents. Many reports claim the antimicrobial nature of these metabolites; unfortunately, the mode of action of such metabolites is not well understood and/or known limited. Henceforth, this review focuses on the properties and potential application, also critically highlighting the possible mechanism of action of these metabolites to offer further translational research. The review also aims to provide a comprehensive insight into current gaps in research on cyanobacterial biology as antimicrobials and hopes to shed light on the importance of continuing research on cyanobacteria metabolites in the search for novel antimicrobials.