AUTHOR=Ke Yefang , Ye Lina , Zhu Pan , Zhu Zhe 

TITLE=The clinical characteristics and microbiological investigation of pediatric burn patients with wound infections in a tertiary hospital in Ningbo, China: A ten-year retrospective study

JOURNAL=Frontiers in Microbiology

VOLUME=Volume 13 - 2022

YEAR=2023

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.1034099

DOI=10.3389/fmicb.2022.1034099

ISSN=1664-302X

ABSTRACT=Burn is one of the leading causes of death and disability in children worldwide, and wound infection is an excellent challenge in burn treatment. We performed a retrospective review of pediatric burn patients with wound infections to reveal their clinical data and investigate pathogens' distribution and drug resistance patterns to provide references for treatment. As a result, 330 pediatric burn patients with wound infections were identified; 65.8% (217/330) were <2 years old. Most of the injuries were scalded and involved <10% total body surface area in size (TBSA), mainly causing Ⅱ-degree burn and Ⅱ+Ⅲ-degree burn. 359 strains of pathogens were isolated, the primary pathogens were Staphylococcus aureus (45.4%) and Pseudomonas aeruginosa (18.7%). Both Staphylococcus aureus and Pseudomonas aeruginosa isolated from 2012-2016 were more likely to be multi-resistant than those isolated from 2017-2021, as they were significantly associated with resistance to ≥ 4 Clinical and Laboratory Standard Institute (CLSI) classes (P=0.040 and 0.006, respectively). In conclusion, children aged <2 years old were the main pediatric burn patients with wound infections. The primary bacteria isolated from the wound were Staphylococcus aureus and Pseudomonas aeruginosa, with a decreasing tendency of multi-resistance.