AUTHOR=Li Shenming , Yang Min , Ji Lei , Fan Hua TITLE=A multi-omics machine learning framework in predicting the recurrence and metastasis of patients with pancreatic adenocarcinoma JOURNAL=Frontiers in Microbiology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.1032623 DOI=10.3389/fmicb.2022.1032623 ISSN=1664-302X ABSTRACT=
Local recurrence and distant metastasis are the main causes of death in patients with pancreatic adenocarcinoma (PDAC). Microbial content in PDAC metastasis is still not well-characterized. Here, the tissue microbiome was comprehensively compared between metastatic and non-metastatic PDAC patients. We found that the pancreatic tissue microbiome of metastatic patients was significantly different from that of non-metastatic patients. Further, 10 potential bacterial biomarkers (