AUTHOR=Palabikyan Hayk , Ruddyard Aquilla , Pomper Lara , Novak David , Reischl Barbara , Rittmann Simon K.-M. R. TITLE=Scale-up of biomass production by Methanococcus maripaludis JOURNAL=Frontiers in Microbiology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.1031131 DOI=10.3389/fmicb.2022.1031131 ISSN=1664-302X ABSTRACT=
The development of a sustainable energy economy is one of the great challenges in the current times of climate crisis and growing energy demands. Industrial production of the fifth-generation biofuel methane by microorganisms has the potential to become a crucial biotechnological milestone of the post fossil fuel era. Therefore, reproducible cultivation and scale-up of methanogenic archaea (methanogens) is essential for enabling biomass generation for fundamental studies and for defining peak performance conditions for bioprocess development. This study provides a comprehensive revision of established and optimization of novel methods for the cultivation of the model organism