AUTHOR=Mohammad Majd , Ali Abukar , Nguyen Minh-Thu , Götz Friedrich , Pullerits Rille , Jin Tao 

TITLE=Staphylococcus aureus lipoproteins in infectious diseases

JOURNAL=Frontiers in Microbiology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.1006765

DOI=10.3389/fmicb.2022.1006765

ISSN=1664-302X

ABSTRACT=<p>Infections with the Gram-positive bacterial pathogen <italic>Staphylococcus aureus</italic> remain a major challenge for the healthcare system and demand new treatment options. The increasing antibiotic resistance of <italic>S. aureus</italic> poses additional challenges, consequently inflicting a huge strain in the society due to enormous healthcare costs. <italic>S. aureus</italic> expresses multiple molecules, including bacterial lipoproteins (Lpps), which play a role not only in immune response but also in disease pathogenesis. <italic>S. aureus</italic> Lpps, the predominant ligands of TLR2, are important for bacterial survival as they maintain the metabolic activity of the bacteria. Moreover, Lpps possess many diverse properties that are of vital importance for the bacteria. They also contribute to host cell invasion but so far their role in different staphylococcal infections has not been fully defined. In this review, we summarize the current knowledge about <italic>S. aureus</italic> Lpps and their distinct roles in various infectious disease animal models, such as septic arthritis, sepsis, and skin and soft tissue infections. The molecular and cellular response of the host to <italic>S. aureus</italic> Lpp exposure is also a primary focus.</p>