AUTHOR=Bai Yu-Bin , Shi Meng-Yan , Wang Wei-Wei , Wu Ling-Yu , Bai Yu-Ting , Li Bing , Zhou Xu-Zheng , Zhang Ji-Yu TITLE=Novel quorum sensing inhibitor Echinatin as an antibacterial synergist against Escherichia coli JOURNAL=Frontiers in Microbiology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.1003692 DOI=10.3389/fmicb.2022.1003692 ISSN=1664-302X ABSTRACT=
A new antibacterial strategy based on inhibiting bacterial quorum sensing (QS) has emerged as a promising method of attenuating bacterial pathogenicity and preventing bacterial resistance to antibiotics. In this study, we screened Echinatin (Ech) with high-efficiency anti-QS from 13 flavonoids through the AI-2 bioluminescence assay. Additionally, crystal violet (CV) staining combined with confocal laser scanning microscopy (CLSM) was used to evaluate the effect of anti-biofilm against