AUTHOR=Yue Qiulin , Wang Zhongjian , Tang Xueyang , Zhao Chen , Li Kunlun , Su Le , Zhang Song , Sun Xin , Liu Xinli , Zhao Lin 

TITLE=Hypolipidemic Effects of Fermented Seaweed Extracts by Saccharomyces cerevisiae and Lactiplantibacillus plantarum

JOURNAL=Frontiers in Microbiology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2021.772585

DOI=10.3389/fmicb.2021.772585

ISSN=1664-302X

ABSTRACT=<p>The fermentation of food materials with suitable probiotic strains is an effective way to improve biological activities. In this study, seaweed extracts were fermented by <italic>Saccharomyces cerevisiae</italic> and <italic>Lactiplantibacillus plantarum</italic>, and the hypolipidemic effects of the fermentation products were investigated. <italic>In vitro</italic> experiments suggested that fermented seaweed extracts have a high capacity for bile acid-binding. Additionally, a significant inhibitory effect against pancreatic lipase was observed. Furthermore, effects in hyperlipidemic mice were determined. Fermented seaweed extracts can alleviate lipid metabolism disorder. The administration of fermented seaweed extracts to mice showed decreased total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) levels and increased high-density lipoprotein cholesterol (HDL-C) levels. Combined, these results suggest that fermented seaweed extracts perform a potent hypolipidemic action, thus providing an effective method for the preparation of functional foods to combat cardiovascular diseases.</p>