AUTHOR=Zhang Luping , Zhou Dengyuan , Li Qiuyan , Zhu Shuo , Imran Muhammad , Duan Hongyu , Cao Shengbo , Ke Shaoyong , Ye Jing TITLE=The Antiviral Effect of Novel Steroidal Derivatives on Flaviviruses JOURNAL=Frontiers in Microbiology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2021.727236 DOI=10.3389/fmicb.2021.727236 ISSN=1664-302X ABSTRACT=
Flaviviruses are the major emerging arthropod-borne pathogens globally. However, there is still no practical anti-flavivirus approach. Therefore, existing and emerging flaviviruses desperately need active broad-spectrum drugs. In the present study, the antiviral effect of steroidal dehydroepiandrosterone (DHEA) and 23 synthetic derivatives against flaviviruses such as Japanese encephalitis virus (JEV), Zika virus (ZIKV), and Dengue virus (DENV) were appraised by examining the characteristics of virus infection both