AUTHOR=Tang Xiaopeng , Liu Xuguang , Zhong Jinfeng , Fang Rejun 

TITLE=Potential Application of Lonicera japonica Extracts in Animal Production: From the Perspective of Intestinal Health

JOURNAL=Frontiers in Microbiology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2021.719877

DOI=10.3389/fmicb.2021.719877

ISSN=1664-302X

ABSTRACT=<p><italic>Lonicera japonica</italic> (<italic>L. japonica</italic>) extract is rich in active substances, such as phenolic acids, essential oils, flavones, saponins, and iridoids, which have a broad spectrum of antioxidant, anti-inflammatory, and anti-microbial effect. Previous studies have demonstrated that <italic>L. japonica</italic> has a good regulatory effect on animal intestinal health, which can be used as a potential antibiotic substitute product. However, previous studies about intestinal health regulation mainly focus on experimental animals or cells, like mice, rats, HMC-1 Cells, and RAW 264.7 cells. In this review, the intestinal health benefits including antioxidant, anti-inflammatory, and antimicrobial activity, and its potential application in animal production were summarized. Through this review, we can see that the effects and mechanism of <italic>L. japonica</italic> extract on intestinal health regulation of farm and aquatic animals are still rare and unclear. Further studies could focus on the regulatory mechanism of <italic>L. japonica</italic> extract on intestinal health especially the protective effects of <italic>L. japonica</italic> extract on oxidative injury, inflammation, and regulation of intestinal flora in farm animals and aquatic animals, thereby providing references for the rational utilization and application of <italic>L. japonica</italic> and its extracts in animal production.</p>