AUTHOR=Mirzaei Bahman , Babaei Ryhaneh , Zeighami Habib , Dadar Maryam , Soltani Ali 

TITLE=Staphylococcus aureus Putative Vaccines Based on the Virulence Factors: A Mini-Review

JOURNAL=Frontiers in Microbiology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2021.704247

DOI=10.3389/fmicb.2021.704247

ISSN=1664-302X

ABSTRACT=<p>Since the 1960s, the frequency of methicillin<italic>-</italic>resistant <italic>Staphylococcus aureus</italic> as a recurrent cause of nosocomial infections has increased. Since multidrug-resistant <italic>Staphylococcus</italic> has overcome antimicrobial treatment, the development of putative vaccines based on virulence factors could be a great help in controlling the infections caused by bacteria and are actively being pursued in healthcare settings. This mini-review provides an overview of the recent progress in vaccine development, immunogenicity, and therapeutic features of some <italic>S. aureus</italic> macromolecules as putative vaccine candidates and their implications against human <italic>S. aureus</italic>-related infections. Based on the reviewed experiments, multivalent vaccines could prevent the promotion of the diseases caused by this bacterium and enhance the prevention chance of <italic>S. aureus</italic> infections.</p>