AUTHOR=Liu Sha-Sha , Yang Li , Kong Fan-Dong , Zhao Jia-Hui , Yao Li , Yuchi Zhi-Guang , Ma Qing-Yun , Xie Qing-Yi , Zhou Li-Man , Guo Meng-Fei , Dai Hao-Fu , Zhao You-Xing , Luo Du-Qiang 

TITLE=Three New Quinazoline-Containing Indole Alkaloids From the Marine-Derived Fungus Aspergillus sp. HNMF114

JOURNAL=Frontiers in Microbiology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2021.680879

DOI=10.3389/fmicb.2021.680879

ISSN=1664-302X

ABSTRACT=<p>By feeding tryptophan to the marine-derived fungus <italic>Aspergillus</italic> sp. HNMF114 from the bivalve mollusk <italic>Sanguinolaria chinensis</italic>, 3 new quinazoline-containing indole alkaloids, named aspertoryadins H–J (<bold>1</bold>–<bold>3</bold>), along with 16 known ones (<bold>4</bold>–<bold>19</bold>), were obtained. The structures of the new compounds were elucidated by the analysis of spectroscopic data combined with quantum chemical calculations of nuclear magnetic resonance (NMR) chemical shifts and electron capture detector (ECD) spectra. Structurally, compound <bold>3</bold> represents the first example of this type of compound, bearing an amide group at C-3. Compounds <bold>10</bold> and <bold>16</bold> showed potent α-glucosidase inhibitory activity with IC<sub>50</sub> values of 7.18 and 5.29 μM, and compounds <bold>13</bold> and <bold>14</bold> showed a clear activation effect on the ryanodine receptor from <italic>Spodoptera frugiperda</italic> (sfRyR), which reduced the [Ca<sup>2+</sup>]<sub><italic>ER</italic></sub> by 37.1 and 36.2%, respectively.</p>