AUTHOR=Pan Guojun , Li Yanling , Che Xinyu , Tian Dan , Han Wenjie , Wang Zimin , Zhao Yanfen , Ren Shuang , Xu Yiru , Hao Gangping , Guo Mengfei , Xiao Na , Kong  Fandong 

TITLE=New Thio-Compounds and Monoterpenes With Anti-inflammatory Activities From the Fungus Aspergillus sp. CYH26

JOURNAL=Frontiers in Microbiology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2021.668938

DOI=10.3389/fmicb.2021.668938

ISSN=1664-302X

ABSTRACT=<p>Two new thio-compounds named aspergerthinol A and B (<bold>1</bold> and <bold>2</bold>) and two new monoterpenes named aspergerthinacids A and B (<bold>3</bold> and <bold>4</bold>) were isolated from the fungus <italic>Aspergillus</italic> sp. CYH26 from the rhizosphere soil of <italic>Cynanchum bungei</italic> Decne. The structures of compounds were elucidated by spectroscopic data and quantum NMR and ECD calculations. Compounds <bold>1</bold> and <bold>2</bold> represented a new family of sulfur containing natural products with a 3-methyl-4<italic>H</italic>-cyclopenta[b]thiophen-4-one skeleton. Compounds <bold>1–4</bold> showed inhibitory activities against nitric oxide (NO) with IC<sub>50</sub> values of 38.0, 19.8, 46.3, and 56.6 μM, respectively.</p>