AUTHOR=Wang Xiaolei , Mehra Smriti , Kaushal Deepak , Veazey Ronald S. , Xu Huanbin 

TITLE=Abnormal Tryptophan Metabolism in HIV and Mycobacterium tuberculosis Infection

JOURNAL=Frontiers in Microbiology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2021.666227

DOI=10.3389/fmicb.2021.666227

ISSN=1664-302X

ABSTRACT=<p>Host metabolism has recently gained more attention for its roles in physiological functions and pathologic conditions. Of these, metabolic tryptophan disorders generate a pattern of abnormal metabolites that are implicated in various diseases. Here, we briefly highlight the recent advances regarding abnormal tryptophan metabolism in HIV and <italic>Mycobacterium tuberculosis</italic> infection and discuss its potential impact on immune regulation, disease progression, and neurological disorders. Finally, we also discuss the potential for metabolic tryptophan interventions toward these infectious diseases.</p>