AUTHOR=Hu Shan , Zhu Feilong , Jiang Weiwei , Wang Yuehua , Quan Yongqiang , Zhang Guoming , Gu Feng , Yang Ying 

TITLE=Retrospective Analysis of the Clinical Characteristics of Candida auris Infection Worldwide From 2009 to 2020

JOURNAL=Frontiers in Microbiology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2021.658329

DOI=10.3389/fmicb.2021.658329

ISSN=1664-302X

ABSTRACT=<sec><title>Introduction</title><p><italic>Candida auris</italic> is an emerging multidrug-resistant fungus that may cause infections with a high mortality rate. The first case of <italic>C. auris</italic> infection was reported in 2009 and infections have been reported in 44 countries. The fungus now represents a major global public health threat. We analyzed cases from the emergence of <italic>C. auris</italic> infections up until the end of 2020. It is hoped that the results of this analysis will raise awareness in scientists to promote protection and control research pertaining to this pathogen.</p></sec><sec><title>Methods</title><p>PubMed and Web of Science databases were searched for all papers related to <italic>C. auris</italic> infections up until December 31, 2020. We sorted and organized these data into the following categories: date of publication, patient age and sex, underlying diseases, risk factors for infection, patient mortality information, drug sensitivity information of <italic>C. auris</italic> isolates, and genetic classification. The χ<sup>2</sup> test was used to screen for factors that may affect patient mortality.</p></sec><sec><title>Results</title><p>A total of 912 patients were included in the analysis. There’s a higher proportion of men and a high proportion of patients were premature babies and elderly people. The proportions of patients with underlying diseases such as diabetes, kidney disease, trauma, and ear disease were also high. More than half of patients had a history of central venous catheter use and a history of broad-spectrum antibiotic use. The χ<sup>2</sup> test revealed that only kidney disease (<italic>P</italic> &lt; 0.05) was an important risk factor for mortality in <italic>C. auris-</italic>infected patients.</p></sec><sec><title>Conclusions</title><p>A comprehensive understanding of <italic>C. auris</italic> was achieved following this retrospective analysis, including the characteristics of <italic>C. auris</italic>-infected patients. In recent years, increasing numbers of multidrug-resistant <italic>C. auris</italic> isolates have been identified, and the high mortality rates associated with infection merit greater attention from the medical world.</p></sec>