AUTHOR=Xu Yanchao , Wang Yong , Wu Dan , He Wenwen , Wang Liping , Zhu Weiming 

TITLE=p-Terphenyls From Aspergillus sp. GZWMJZ-055: Identification, Derivation, Antioxidant and α-Glycosidase Inhibitory Activities

JOURNAL=Frontiers in Microbiology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2021.654963

DOI=10.3389/fmicb.2021.654963

ISSN=1664-302X

ABSTRACT=<p>One new (<bold>1</bold>) and fifteen known (<bold>2</bold>–<bold>16</bold>) <italic>p</italic>-terphenyls were isolated from a solid culture of the endophytic fungus <italic>Aspergillus</italic> sp. GZWMJZ-055 by adding the leaves of its host <italic>Eucommia ulmoides</italic>. Furthermore, nine <italic>p</italic>-terphenyls (<bold>17</bold>–<bold>25</bold>) were synthesized from the main compounds (<bold>5</bold>–<bold>7</bold>), among which derivatives <bold>18</bold>, <bold>19</bold>, <bold>21</bold>, <bold>22</bold>, and <bold>25</bold> are new <italic>p</italic>-terphenyls. Compounds <bold>15</bold> and <bold>16</bold> were also, respectively, synthesized from compounds <bold>6</bold> and <bold>7</bold> by oxidative cyclization of air in the presence of silica gel. These <italic>p</italic>-terphenyls especially those with 4,2′,4″-trihydroxy (<bold>4</bold>–<bold>7</bold>, <bold>20</bold>, <bold>21</bold>) or 4, 4″-dihydroxy-1,2,1′,2′-furan (<bold>15</bold>, <bold>16</bold>) substituted nucleus, exhibited significant antioxidant and α-glucosidase inhibitory activities and lower cytotoxicity to caco-2 cells. The results indicated their potential use as lead compounds or dietary supplements for treating or preventing the diabetes.</p>