AUTHOR=Yuan Li , Wang Wei , Zhang Wei , Zhang Yan , Wei Chong , Li Jingnan , Zhou Daobin TITLE=Gut Microbiota in Untreated Diffuse Large B Cell Lymphoma Patients JOURNAL=Frontiers in Microbiology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2021.646361 DOI=10.3389/fmicb.2021.646361 ISSN=1664-302X ABSTRACT=
Intestinal microecology plays an important role in the development and progression of hematological malignancies. However, characteristics of gut microbiota in diffuse large B cell lymphoma (DLBCL) have not been reported. The microbiota composition of fecal samples from 25 untreated DLBCL patients and 26 healthy volunteers was examined by 16S rRNA gene sequencing. On α-diversity analysis, there was no significant difference in species diversity and abundance between the two groups. However, a significant difference was observed on β-diversity analysis. The intestinal microbiota in patients with DLBCL showed a continuous evolutionary relationship, which progressed from phylum,