AUTHOR=Han Yiwen , Liu Zhaoxia , Chen Tingtao 

TITLE=Role of Vaginal Microbiota Dysbiosis in Gynecological Diseases and the Potential Interventions

JOURNAL=Frontiers in Microbiology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2021.643422

DOI=10.3389/fmicb.2021.643422

ISSN=1664-302X

ABSTRACT=<p>Vaginal microbiota dysbiosis, characterized by the loss of <italic>Lactobacillus</italic> dominance and increase of microbial diversity, is closely related to gynecological diseases; thus, intervention on microbiota composition is significant and promising in the treatment of gynecological diseases. Currently, antibiotics and/or probiotics are the mainstay of treatment, which show favorable therapeutic effects but also bring problems such as drug resistance and high recurrence. In this review, we discuss the role of vaginal microbiota dysbiosis in various gynecological infectious and non-infectious diseases, as well as the current and potential interventions.</p>