AUTHOR=Liu Gaoran , Huo Ruiyun , Zhai Yanan , Liu Ling 

TITLE=New Bioactive Sesquiterpeniods From the Plant Endophytic Fungus Pestalotiopsis theae

JOURNAL=Frontiers in Microbiology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2021.641504

DOI=10.3389/fmicb.2021.641504

ISSN=1664-302X

ABSTRACT=<p>Three new secondary metabolites pestalothenins A–C (<bold>1</bold>–<bold>3</bold>), including two new humulane-derived sesquiterpeniods (<bold>1</bold> and <bold>2</bold>) and one new caryophyllene-derived sesquiterpeniod (<bold>3</bold>), together with five known compounds (<bold>4</bold>–<bold>8</bold>) were isolated from the crude extract of the plant endophytic fungus <italic>Pestalotiopsis theae</italic> (N635). Their structures were elucidated by the extensive analyses of HRESIMS and NMR spectroscopic data. The absolute configurations of <bold>1</bold>–<bold>3</bold> were determined by comparison of experimental and calculated electronic circular dichroism (ECD) spectra. The cytotoxic effects of these compounds were evaluated <italic>in vitro</italic>. Compound <bold>6</bold> showed moderate cytotoxicity against T24 and MCF7 cell lines. In addition, compounds <bold>1</bold>–<bold>8</bold> were also evaluated for antibacterial activity.</p>