AUTHOR=Thompson Aiysha , da Fonseca Diogo M. , Walker Louise , Griffiths James S. , Taylor Philip R. , Gow Neil A. R. , Orr Selinda J. 

TITLE=Dependence on Mincle and Dectin-2 Varies With Multiple Candida Species During Systemic Infection

JOURNAL=Frontiers in Microbiology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2021.633229

DOI=10.3389/fmicb.2021.633229

ISSN=1664-302X

ABSTRACT=<p>More than 95% of invasive <italic>Candida</italic> infections are caused by four <italic>Candida</italic> spp. (<italic>C. albicans, C. glabrata, C. tropicalis, C. parapsilosis</italic>). C-type lectin-like receptors (CLRs), such as Dectin-1, Dectin-2, and Mincle mediate immune responses to <italic>C. albicans</italic>. Dectin-1 promotes clearance of <italic>C. albicans, C. glabrata, C. tropicalis</italic>, and <italic>C. parapsilosis</italic>, however, dependence on Dectin-1 for specific immune responses varies with the different <italic>Candida</italic> spp. Dectin-2 is important for host immunity to <italic>C. albicans</italic> and <italic>C. glabrata</italic>, and Mincle is important for the immune response to <italic>C. albicans.</italic> However, whether Dectin-2 drives host immunity to <italic>C. tropicalis</italic> or <italic>C. parapsilosis</italic>, and whether Mincle mediates host immunity to <italic>C. glabrata, C. tropicalis</italic> or <italic>C. parapsilosis</italic> is unknown. Therefore, we compared the roles of Dectin-2 and Mincle in response to these four <italic>Candida</italic> spp. We demonstrate that these four <italic>Candida</italic> spp. cell walls have differential mannan contents. Mincle and Dectin-2 play a key role in regulating cytokine production in response to these four <italic>Candida</italic> spp. and Dectin-2 is also important for clearance of all four <italic>Candida</italic> spp. during systemic infection. However, Mincle was only important for clearance of <italic>C. tropicalis</italic> during systemic infection. Our data indicate that multiple <italic>Candida</italic> spp. have different mannan contents, and dependence on the mannan-detecting CLRs, Mincle, and Dectin-2 varies between different <italic>Candida</italic> spp. during systemic infection.</p>