AUTHOR=Camus Laura , Briaud Paul , Vandenesch François , Moreau Karen 

TITLE=How Bacterial Adaptation to Cystic Fibrosis Environment Shapes Interactions Between Pseudomonas aeruginosa and Staphylococcus aureus

JOURNAL=Frontiers in Microbiology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2021.617784

DOI=10.3389/fmicb.2021.617784

ISSN=1664-302X

ABSTRACT=<p><italic>Pseudomonas aeruginosa</italic> and <italic>Staphylococcus aureus</italic> are the two most prevalent bacteria species in the lungs of cystic fibrosis (CF) patients and are associated with poor clinical outcomes. Co-infection by the two species is a frequent situation that promotes their interaction. The ability of <italic>P. aeruginosa</italic> to outperform <italic>S. aureus</italic> has been widely described, and this competitive interaction was, for a long time, the only one considered. More recently, several studies have described that the two species are able to coexist. This change in relationship is linked to the evolution of bacterial strains in the lungs. This review attempts to decipher how bacterial adaptation to the CF environment can induce a change in the type of interaction and promote coexisting interaction between <italic>P. aeruginosa</italic> and <italic>S. aureus</italic>. The impact of coexistence on the establishment and maintenance of a chronic infection will also be presented, by considering the latest research on the subject.</p>