AUTHOR=Li Hai-bei , Hou Ai-ming , Chen Tian-jiao , Yang Dong , Chen Zheng-shan , Shen Zhi-qiang , Qiu Zhi-gang , Yin Jing , Yang Zhong-wei , Shi Dan-yang , Wang Hua-ran , Li Jun-wen , Jin Min 

TITLE=Decreased Antibiotic Susceptibility in Pseudomonas aeruginosa Surviving UV Irradition

JOURNAL=Frontiers in Microbiology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2021.604245

DOI=10.3389/fmicb.2021.604245

ISSN=1664-302X

ABSTRACT=<p>Given its excellent performance against the pathogens, UV disinfection has been applied broadly in different fields. However, only limited studies have comprehensively investigated the response of bacteria surviving UV irradiation to the environmental antibiotic stress. Here, we investigated the antibiotic susceptibility of <italic>Pseudomonas aeruginosa</italic> suffering from the UV irradiation. Our results revealed that UV exposure may decrease the susceptibility to tetracycline, ciprofloxacin, and polymyxin B in the survival <italic>P. aeruginosa</italic>. Mechanistically, UV exposure causes oxidative stress in <italic>P. aeruginosa</italic> and consequently induces dysregulation of genes contributed to the related antibiotic resistance genes. These results revealed that the insufficient ultraviolet radiation dose may result in the decreased antibiotic susceptibility in the pathogens, thus posing potential threats to the environment and human health.</p>