AUTHOR=Avila-Calderón Eric Daniel , Ruiz-Palma María del Socorro , Aguilera-Arreola Ma. Guadalupe , Velázquez-Guadarrama Norma , Ruiz Enrico A. , Gomez-Lunar Zulema , Witonsky Sharon , Contreras-Rodríguez Araceli 

TITLE=Outer Membrane Vesicles of Gram-Negative Bacteria: An Outlook on Biogenesis

JOURNAL=Frontiers in Microbiology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2021.557902

DOI=10.3389/fmicb.2021.557902

ISSN=1664-302X

ABSTRACT=<p>Outer membrane vesicles (OMVs) from Gram-negative bacteria were first described more than 50 years ago. However, the molecular mechanisms involved in biogenesis began to be studied only in the last few decades. Presently, the biogenesis and molecular mechanisms for their release are not completely known. This review covers the most recent information on cellular components involved in OMV biogenesis, such as lipoproteins and outer membrane proteins, lipopolysaccharide, phospholipids, quorum-sensing molecules, and flagella.</p>