AUTHOR=Xie Chun-Lan , Zhang Duo , Lin Ting , He Zhi-Hui , Yan Qing-Xiang , Cai Qi , Zhang Xiao-Kun , Yang Xian-Wen , Chen Hai-Feng 

TITLE=Antiproliferative Sorbicillinoids From the Deep-Sea-Derived Penicillium allii-sativi

JOURNAL=Frontiers in Microbiology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2020.636948

DOI=10.3389/fmicb.2020.636948

ISSN=1664-302X

ABSTRACT=<p>Two new (<bold>1</bold>–<bold>2</bold>) and three known (<bold>3</bold>–<bold>5</bold>) sorbicillinoids were isolated from the deep-sea-derived fungus <italic>Penicillium allii-sativi</italic> MCCC 3A00580. Compounds <bold>1</bold> and <bold>2</bold>, named sorbicatechols C and D, were two new hybrid dihydrosorbillinoids. Their structures were established mainly by spectroscopic analyses and electronic circular dichroism (ECD) calculations. All five isolates were tested for antiproliferative activities against four tumor cell lines of MCF-7, HT-29, HuH-7, and LNCap. Compounds <bold>2</bold> and <bold>5</bold> inhibited HT-29 cells in a good dose-dependent manner. Mechanism investigation uncovered that they could significantly induce cell cycle G2-M phase arresting by increasing the protein levels of p-H3 and cyclin B1.</p>