AUTHOR=Song Zhiqi , Bao Linlin , Yu Pin , Qi Feifei , Gong Shuran , Wang Jie , Zhao Binbin , Liu Mingya , Han Yunlin , Deng Wei , Liu Jiangning , Wei Qiang , Xue Jing , Zhao Wenjie , Qin Chuan TITLE=SARS-CoV-2 Causes a Systemically Multiple Organs Damages and Dissemination in Hamsters JOURNAL=Frontiers in Microbiology VOLUME=11 YEAR=2021 URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2020.618891 DOI=10.3389/fmicb.2020.618891 ISSN=1664-302X ABSTRACT=
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has spread across the world and impacted global healthcare systems. For clinical patients, COVID-19 not only induces pulmonary lesions but also affects extrapulmonary organs. An ideal animal model that mimics COVID-19 in humans in terms of the induced systematic lesions is urgently needed. Here, we report that Syrian hamster is highly permissive to SARS-CoV-2 and exhibit diffuse alveolar damage and induced extrapulmonary multi-organs damage, including spleen, lymph nodes, different segments of alimentary tract, kidney, adrenal gland, ovary, vesicular gland and prostate damage, at 3–7 days post inoculation (dpi), based on qRT-PCR,