AUTHOR=Liu Huhu , Song Yulan , Fan Xiao , Wang Chong , Lu Xiangyang , Tian Yun 

TITLE=Yarrowia lipolytica as an Oleaginous Platform for the Production of Value-Added Fatty Acid-Based Bioproducts

JOURNAL=Frontiers in Microbiology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2020.608662

DOI=10.3389/fmicb.2020.608662

ISSN=1664-302X

ABSTRACT=<p>The microbial fermentation process has been used as an alternative pathway to the production of value-added natural products. Of the microorganisms, <italic>Yarrowia lipolytica</italic>, as an oleaginous platform, is able to produce fatty acid-derived biofuels and biochemicals. Nowadays, there are growing progresses on the production of value-added fatty acid-based bioproducts in <italic>Y</italic>. <italic>lipolytica</italic>. However, there are fewer reviews performing the metabolic engineering strategies and summarizing the current production of fatty acid-based bioproducts in <italic>Y. lipolytica</italic>. To this end, we briefly provide the fatty acid metabolism, including fatty acid biosynthesis, transportation, and degradation. Then, we introduce the various metabolic engineering strategies for increasing bioproduct accumulation in <italic>Y. lipolytica</italic>. Further, the advanced progress in the production of fatty acid-based bioproducts by <italic>Y. lipolytica</italic>, including nutraceuticals, biofuels, and biochemicals, is summarized. This review will provide attractive thoughts for researchers working in the field of <italic>Y. lipolytica</italic>.</p>